920509-32-6 resmetirom

Properti

Penampilan Yellow to Oranye Crystalline Solid
Kepadatan 1.65 ± 0. 1 g/cm3
suhu penyimpanan. Inert Atmosphere, simpan di freezer, di bawah -20 derajat
Kelarutan DMSO: 59. 0 (Max Conc. Mg/ml); 135.56 (Max Conc. Mm)
pKa3.96 ± 0. 40
 

Aplikasi:

Resmetirom adalah agonis selektif yang menargetkan beta reseptor hormon tiroid (THR -). Obat ini dapat secara khusus diambil oleh sel -sel hati dan mengatur beberapa jalur metabolisme di hati dengan mengaktifkan THR -, dengan demikian mencapai beberapa efek seperti mengurangi akumulasi lemak hati, mempromosikan metabolisme asam lemak, mengurangi peradangan hati, dan mengatur metabolisme kolesterol.

 

Sinonim:

Resmetirom

Mgl -3196

920509-32-6

Rezdiffra

2- [3, 5- Dichloro -4- [(6- oxo -5- propan -2- yl -1 h-pyridazin {{9} } yl) oxy] phenyl] -3, 5- dioxo -1, 2, 4- triazine -6- carbonitrile

Senyawa 53 [PMID: 24712661]

1,2, 4- triazine -6- carbonitrile, 2- (3, 5- dikloro -4- ((1, 6- dihydro -5- ({1- methylethyl) -6- ox o -3- pyridazinyl) oxy) phenyl) -2, 3,4, 5- tetrahydro -3, 5- dioxo-

2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)ox y) fenil) -3, 5- dioxo -2, 3,4, 5- tetrahydro- (1,2,4) triazine -6- carbonitrile

Senyawa 53 (PMID: 24712661)

1,2, 4- triazine -6- carbonitrile, 2- [3, 5- dikloro -4- [[1, 6- dihydro -5- (1- methylethyl) -6- ox o -3- pyridazinyl] oxy] phenyl] -2, 3,4, 5- tetrahydro -3, 5- dioxo-

resmetiromum

Rezdiffra

2- (3, 5- dichloro -4- (({6- oxo -5- (propan {{6} {{7 {7} {{8 {{8 {{{8 {8 {{{8 {8 {{{8 {{{8 {{{8 {{{8 {{{8 {{{8 {{{8 {{{8 {{{8 {{{{8 {{{{8 {{{{8 {{{{8 {{{{8 {{{8 {{{{8 {{{8 {{{{8 {{{{8 {{{{8 {{{{8 {{{{8 { ) phenyl) -3, 5- dioxo -2, 3,4, 5- tetrahydro {{16}, 2, {4- triazine -6- carbonrile

2- (3, 5- Dichloro -4- ((6- oxo -5- propan -2- yl -1 h-pyridazin {{9} } yl) oxy) phenyl) -3, 5- dioxo -1, 2, 4- triazine -6- carbonitrile

2-(3,5-dichloro-4-{[6-oxo-5-(propan-2-yl)-1,6-dihydropyridazin-3-yl]oxy } phenyl) -3, 5- dioxo -2, 3,4, 5- tetrahydro {{16}, 2, 4- triazine -6- carbonrile

2- {3, 5- Dichloro -4- [(5- isopropyl -6- oxo -1 h-pyridazin -3- yl) o Xy] phenyl} -3, 5- dioxo -4 h -1, 2, 4- triazine -6- carbonitrile

2-(3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)ph encyl) -3, 5- dioxo -2, 3,4, 5- tetrahydro -1, 2, 4- triazine -6- carbonrile

2- (4- (1, 6- dihydro -5- isopropyl -6- oxopyridazin -3- yloxy) {{7}, 5- dlor encyl) -2, 3,4, 5- tetrahydro -3, 5- dioxo -1, 2, {17}} triazine -6- carbonrile

2- [3, 5- Dichloro -4- (5- isopropyl -6- oxo {{6}, 6- diHydro-pyridazin {{{9 {9} {9 {9} {{9 {9 {9 {9 {9 {9 {{9 {9 {9 {9 {9 {{9 {9 {9 {{9 {9 {9 {9 {9 {9 {9 ) -phenyl] -3, 5- dioxo -2, 3,4, 5- tetrahydro- [1,2,4] triazine -6- carbonitrile

2- [3, 5- Dichloro -4- [[1, 6- dihydro -5- (1- methylethyl) -6- {{{7} {{{{{{{{{{{{{{{{{9 {9 {9 {9 {{{{{{{{{{{{{{{{{{{{{{{{{{8, ] fenil] -2, 3,4, 5- tetrahydro -3, {5- dioxo {{16}, 2, {18}} triazine -6- carbonrile

 

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