1442472-39-0 ripretinib

Properti

Penampilan putih hingga ringan padat kuning
Titik didih: 568.6 ± 5 0. 0 derajat
Kepadatan 1.544 ± 0. 06 g/cm3
suhu penyimpanan. Simpan di -20 derajat
Kelarutan DMSO: 25. 0 (max conc. mg/ml); 49. 0 (max conc. mm)
pKa12.15 ± 0. 70
 

Aplikasi:

Ripretinib adalah inhibitor tirosin kinase yang terutama bertindak pada kit dan pDGFRA kinase, dan cocok untuk merawat pasien dewasa GIST yang telah menerima pengobatan dengan tiga atau lebih inhibitor kinase, termasuk imatinib.
 

 

Sinonim:

Ripretinib

1442472-39-0

DCC -2618

N-{4- bromo -5- [1- ethyl -7- (methylamino) {{5} } oxo -1, 2- dihydro -1, 6- naphthyridin -3- yl] -2- fluorophenyl} -n'-phenylurea

Urea, n-[4- bromo -5- [1- ethyl -1, {2- {7} {{6 {6} {8 {{8 {{8 {{8 {{{Methylamino {{Methylamino {{{Methylamino {{{Methylamino {{Methylamino {{Methylamino {{Methylamino, naphthyridin -3- yl] -2- fluorophenyl] -n'-phenyl -39-0

Qinlock

Basis bebas ripretinib

Quinlock

1- (4- bromo -5- (1- ethyl -7- (methylamino) -2- oxo {{6},, 2-}} di Hydro -1, 6- naphthyridin -3- yl) -2- fluorophenyl) -3- phenylurea

Ripretinib

1442472-39-0 (basis gratis)

Urea, N-(4- bromo -5- ({1- ethyl -1, 2- dihydro -7- (methylamino) {{{{{{6} (methylamino) 7}} oxo -1, 6- naphthyridin -3- yl) -2- fluorophenyl) -n'-phenyl-

N-(4- bromo -5- ({1- ethyl -7- (methylamino) -2- oxo -1, 2- diH ydro -1, 6- naphthyridin -3- yl) -2- fluorophenyl) -n'-phenylurea

1- [4- bromo -5- [1- ethyl -7- (methylamino) -2- oxo {{{6 }}, 6- naphthyridin -3- yl] -2- fluorophenyl] -3- phenylurea

ripretinibum

3- {4- bromo -5- [1- ethyl -7- (methylamino) -2- oxo {{{6 }}, 6- naphthyridin -3- yl] -2- fluorophenyl} -1- phenylurea

C24H21BRFN5O2

Ripretinib (dcc -2618)

Kit/PDGFR Inhibitor DCC -2618

DCC 2618; DCC2618; inhibitor kit/PDGFR; ripretinib

1- n '-(2, 5- difluoro -4- (2- (1- methylpyrazol -4- yl) pyridin -4- yl) oxyphenyl) -1- n'-fenylcyclopropane -1, 1- dicarboxamide

3- {4- bromo -5- [1- ethyl -7- (methylamino) -2- oxo -1, 2-}} di Hydro -1, 6- naphthyridin -3- yl] -2- fluorophenyl} -1- phenylurea

Ripretinib; Urea, N-[4- bromo -5- [{1- ethyl -1, 2- dihydro -7- (methylamino) {{7 }} oxo -1, 6- naphthyridin -3- yl] -2- fluorophenyl] -n'-phenyl-; N-[4- bromo -5- [1- ethyl -1, 2- dihydro -7- (methylamino) {{2 2}} oxo -1, 6- naphthyridin -3- yl] -2- fluorophenyl] -n'-phenylurea; 1- [4- bromo -5- [1- ethyl -7- (methyla

 

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