515814-01-4 voclosporin

Properti

Penampilan putih hingga pucat padat
Titik didih: 13 0 3.8 ± 65.0 derajat
Kepadatan 1. 0 16 ± 0,06 g/cm3
suhu penyimpanan. Simpan di -20 derajat
kelarutan benzena (sedikit), metanol (sedikit)
PKA13.32 ± 0. 70
 

Aplikasi:

Voclosporin adalah inhibitor fosfatase yang diatur kalsium baru, secara struktural mirip dengan siklosporin A. Setelah modifikasi, aktivitasnya meningkat dengan {3-4 kali, dan memiliki mekanisme ganda dan sinergis. Dengan menghambat fosfatase yang diatur kalsium, dapat memblokir ekspresi IL -2 dan respon imun yang dimediasi sel T, menstabilkan podosit ginjal. Dibandingkan dengan siklosporin, vokyclosporine juga memiliki keuntungan lebih sedikit dampak pada kolesterol dan trigliserida, dan risiko diabetes yang lebih rendah.

 

Sinonim:

Voclosporin

515814-01-4

Luveniq

LUPKYNIS

Voclosporine

voclosporina

R 1524

R-1524

(3S, 6S, 9S, 12R, 15S, 18S, 21S, 24S, 30S, 33S) -30- ethyl -33- [(1r, 2r, 4e) -1- hydroxy -2- m Ethylhepta -4, 6- dienyl] -1, 4,7,10,12,15,19,25, 28- nonamethyl {{28}, 9,18, {{3 1}} tetrakis (2- methylpropyl) -3, 21- di (propan -2- yl) -1, 4,7,10,13,16,19,2 2,25,28, 31- Undecazacyclotritriacontane -2, 5,8,11,14,17,20,23,26,29, 32- Undecone

Voclosporin-d4

Cyclosporin a, 6- ((2s, 3r, 4r) -3- hidroksi -4- methyl -2- (methylamino) {{7}, {8- nonadienoic)-

(3S, 6S, 9S, 12R, 15S, 18S, 21S, 24S, 30S, 33S) -30- ethyl -33- ((1r, 2r, e) -1- Hydroxy {{15 }}methylhepta-4,6-dien-1-yl)-6,9,18,24-tetraisobutyl-3,21- Diisopropyl -1, 4,7,10,12,15,19,25, 28- nonamethyl {{34}, 4,7,10,13,16,19,22,25, 28, 31- Undecaazacyclotritriacontan -2, 5,8,11,14,17,20,23,26,29, 32- undecaone

Siklo (((E, z)-(2s, 3r, 4r) -3- hydroxy -4- methyl -2- (methylamino) nona {{7}, {8- {8-methyl-nin {{8 {8 {8 {8 {8 {8 {8 {8 {{8 {8 {{8 {8 {8 {8 { L-N-Methyl-L-Leucyl-L-Valyl-N-Methyl-L-Leucyl-L-Alanyl-D-Alanyl-N-Methyl-L-Leucyl-N-Methyl-L-Leucyl-N-Methyl-L-Valyl))

voclosporinum

LUPKYNIS

1, 11- anhydro (l-alanyl-d-alanyl-nethyl-l-leucyl-nethyl-l-leucyl- N-metil-l-valyl-((2s, 3r, 4r, 6e) -3- hydroxy -4- methyl - 2- (methylamino) nona {{25}, {{8- {{28 {{28 {28 {{28 {{25 {{28 {{28 {{25 {{25 {2. N-methylglycyl-n-metil-l-leucyl-l-valyl-n-metil-l-leusin)

Lx -214

Isatx -247; Luveniq

6- [(2s, 3r, 4r, 6e) -3- hydroxy -4- methyl -2- (methylamino) {{8}, {8- asam nonadienoat] cyclosporoic a

Voclosporin

EX-A5922

AT27977

; y -2- methylhepta -4, {6- dien -1- yl) -6, 9,18, 24- Tetraisobutyl {{{{{{{{{22} {{22 {22 23}}, 21- diisopropyl -1, 4,7,10,12,15,19,25, 28- nonamethyl -1, 4,7,10 , 13,16,19,22,25,28, 31- undecaazacyclotritriacontan -2, 5,8,11,14,17,20,23

6- [(2s, 3r, 4r, 6e) -3- hydroxy -4- methyl -2- (methylamino) {{8}, {8- asam nonadienoat] cyclosporoic a; cyclosporoic acycosporoic a nonadienoic asam cyclosporoic a;

Siklo (l-alanyl-d-alanyl-n-metil-l-leucyl-n-methyl-l-leucyl-n-methyl-l-valyl- ((2s, 3r, 4r, 6e) -3- hydroxy -4- methyl -2- (methylamino) nona {{23}, 8- dienoyl)-(2s) {27} Aminobutanoyl-n-methylglycyl-n-methyl-l-leucyl-l-valyl-n-methyl-l-leucyl)

Siklo (l-alanyl-d-alanyl-n-metil-l-leucyl-n-methyl-l-leucyl-nethyl-l-valyl-((2s, 3r, 4r, 6e) -3- hydroxy -4- methyl -2-

 

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