1223403-58-4 larotrectinib

Properti

Penampilan kuning padat
Kepadatan 1.55 ± 0. 1 g/cm3
suhu penyimpanan. Rt
Kelarutan larut dalam DMSO (hingga 5 mg/ml).
pKa8.41 ± 0. 40
 

Aplikasi:

Larotrectinib adalah inhibitor TRK yang sangat selektif yang secara khusus menargetkan tumor dengan fusi gen NTRK dan menunjukkan efek penghambatan yang signifikan.

 

Sinonim:

Larotrectinib

1223403-58-4

(S) -n-(5- ((r) -2- (2, 5- difluorophenyl) pyrrolidin -1- yl) pirazol o [1, 5- a] pyrimidin -3- yl) -3- hydroxypyrrolidine -1- carboxamide

Loxo 101

Vitrakvi

(3s) -n-[5- [(2r) -2- (2, 5- difluorophenyl) pyrrolidin -1- yl] pirazol o [1, 5- a] pyrimidin -3- yl] -3- hydroxypyrrolidine -1- carboxamide

1- pyrrolidineCarboxamide, -2- (2, 5- difluorophenyl) -1- pyrrolidinyl] pyrazolo [1, 5- a] pyrimidin {{{10 {{9} {{9 {9} {{9 {9 {9 {9 {9 {9 (3s)-

Larotrectinib (loxo -101 basis gratis)

1- pyrrolidineCarboxamide, -2- (2, 5- difluorophenyl) -1- pyrrolidinyl) pirazolo (1, 5- a) pyrimidin {{{10 {{9} {{9 {9} {{9 {9 {9 {9 {9 {9 {9 {9 (3s)-

Larotrectinibum

(3s) -n-(5- ((2r) -2- (2, 5- difluorophenyl) pyrrolidin -1- yl) pirazol o (1, 5- a) pyrimidin -3- yl) -3- hydroxypyrrolidine -1- carboxamide

Larotrectinib (standar)

Arry -470; Larotrectinib

C21H22F2N6O2

(3s) -n-(5- ((2r) -2- (2, 5- difluorophenyl) pyrrolidin - 1- yl) pirazol O (1, 5- a) pyrimidin -3- yl) -3- hydroxypyrrolidine - 1- carboxamide

(3s) -n-(5- ((2r) -2- (2, 5- difluorophenyl) pyrrolidin -1- yl) pirazol o (1, 5- a) pyrimidin -3- yl) -3- hydroxypyrrolidine - 1- carboxamide

(3s) -n-(5- (2- (2, 5- difluorophenyl) pyrrolidin -1- yl) pirazolo (1, 5- a) pyrimidin -3- yl) -3- hydroxypyrrolidine -1- carboxamide

 

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